Evaluation of Anti-Inflammatory and Analgesic

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Evaluation of Anti-Inflammatory and Analgesic

A new series of novel derivatives of pyrazole were synthesized. These derivatives were identified on the basis of melting point range, Rf values, IR and 1H NMR spectral analysis. The derivatives were screened for antiinflammatory and analgesic activities. The derivatives exhibited significant to moderate anti-inflammatory and analgesic activities.

Nitrogen containing heterocyclic compounds are synthetically the challenging models for a number of therapeutically significant products. Azoles occupy a domain of interest in natural and synthetic chemistry. Diazoles are the central building blocks for synthesizing compound libraries in pharmaceutical and agrochemical industries. One such class of compounds includes Pyrazole. Pyrazole refers to the simple doubly unsaturated compound containing two nitrogen (in neighbouring position) and three carbon atoms in the ring.

The research work was oriented towards the finding of novel derivatives of pyrazole with enhance antiinflammatory and analgesic activities. The different derivatives were synthesized. The synthesized derivatives showed very good anti-inflammatory and analgesic activities against previously reported derivatives of pyrazole.

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Asian Journal of Biomedical and Pharmaceutical Sciences
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