Adult Neurogenesis: Beyond Rats and Mice



Every machine requires regular maintenance and replacement of old, worn out parts. Most biological tissues routinely replace old cells with new ones. Unlike other tissues, the nervous system–being the most complex biological device found in nature–uniquely maintains most of its neurons throughout life and replaces relatively few. It preserves hotspots where it generates new neurons from resident stem cells during adulthood in a process known as adult neurogenesis, which varies among different species in its features, dynamics and regulation. In spite of its widespread prevalence in the animal kingdom, the preponderance of studies conducted on a few laboratory rodent species such as rats and mice limits our understanding of the evolution, regulation and function of adult neurogenesis. The anatomy, complexity and functions of the brain vary greatly in the animal kingdom: from simple bilaterians to humans. Therefore, both comparative and focused studies on different species will shed more light on the origin, development and purpose of adult neurogenesis.

Adult neurogenesis was discovered and described by Joseph Altman and Gopal Das in rats and has been investigated in many species such as the zebrafish, frog, songbird, mole, mole-rat, vole, bat, fox, dolphin, elephant, shrew, monkey, and human. With the development of genetic manipulation techniques, researchers have focused largely on inbred laboratory rodents. While this provides a strong advantage of restricting genetic variation in the group, it also narrows our perspective on adult neurogenesis as a biological phenomenon. Moreover, the rapid development of genetic tools has made Mus musculus the species of choice in studying adult neurogenesis. This remains the predominant deterrant against the use of unconventional animal models and leaves some challenging open questions.

•              How did adult neurogenesis evolve?

•              Does our survival depend on adult neurogenesis?

•              What is the link between adult neurogenesis and brain complexity?

•              How do adult neurogenesis and animal behaviour influence each other?

•              How does adult neurogenesis contribute to brain plasticity and cognition?

•              How do experimental conditions affect adult neurogenesis?

Studying unconventional species will give us insights into the evolution and function of the brain, strengthen our understanding of the cellular basis of cognition and behaviour, and help adult neurogenesis find its place in the puzzle. With this Research Topic we endeavour to answer the open questions in the field and encourage engaging discussions on the comparative and evolutionary aspects of adult neurogenesis. This Research Topic aims to showcase the latest studies on adult neurogenesis in wild and uncommon laboratory animals by encouraging primary research articles, opinions, and perspectives to fill the gaps in our knowledge of the generation of new neurons in the adult brain.

International Journal of Pure and Applied Zoology is now accepting submissions on this topic. A standard EDITORIAL TRACKING SYSTEM is utilized for manuscript submission, review, editorial processing and tracking which can be securely accessed by the authors, reviewers and editors for monitoring and tracking the article processing. Manuscripts can be uploaded online at Editorial Tracking System ( or forwarded to the Editorial Office at

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Liza Smith
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International Journal of Pure and Applied Zoology